ERLIN1 and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ERLIN1	BNIP2
Description		ER lipid raft associated 1	BCL2 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding	GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process	Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Response To Oxygen-glucose Deprivation
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		7 interacting genes: AGR3 BNIP2 FA2H RBFA SEC22A SEC23A TMEM199	56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A
Entrez ID		10613	663
HPRD ID		08502	04481
Ensembl ID		ENSG00000107566	ENSG00000140299
Uniprot IDs		O75477	J3KN59 Q12982
PDB IDs
Enriched GO Terms of Interacting Partners?
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