TMEM199 and ELOVL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM199	ELOVL4
Description		transmembrane protein 199	ELOVL fatty acid elongase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity
	Biological Process	Cellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process	Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways			Synthesis of very long-chain fatty acyl-CoAs
Drugs			Omega-3-carboxylic acids
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Osteoprotegerin levels ( 25080503) Triglyceride levels ( 32203549)	Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Partial epilepsies ( 20522523) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: AQP6 BIK CCR2 CD300A EBP ELOVL4 ERLIN1 IFNGR2 JAGN1 KASH5 LMNA REEP4 SLC10A4 STX1A STX4 TIMMDC1 TMEM14B	95 interacting genes: ADGRE2 ANKRD46 APOL3 ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 ITGAM JAGN1 LEPROTL1 LHFPL5 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SNORC STX3 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM199 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB YIF1A YIPF6 ZDHHC21 ZFPL1
Entrez ID		147007	6785
HPRD ID		12679	05697
Ensembl ID		ENSG00000244045	ENSG00000118402
Uniprot IDs		Q8N511	Q9GZR5
PDB IDs
Enriched GO Terms of Interacting Partners?
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