ERLIN1 and SEC22A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		ERLIN1	SEC22A
Description		ER lipid raft associated 1	SEC22 homolog A, vesicle trafficking protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding	Transporter Activity Protein Binding
	Biological Process	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		7 interacting genes: AGR3 BNIP2 FA2H RBFA SEC22A SEC23A TMEM199	106 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC14A2 SLC30A2 SLC35C2 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27
Entrez ID		10613	26984
HPRD ID		08502	15313
Ensembl ID		ENSG00000107566	ENSG00000121542
Uniprot IDs		O75477	Q96IW7
PDB IDs
Enriched GO Terms of Interacting Partners?
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