UBE4B and GZMB

Number of citations of the paper that reports this interaction (PubMedID 11802788)
12

Data Source:
HPRD (in vitro)

		UBE4B	GZMB
Description		ubiquitination factor E4B	granzyme B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle Cytolytic Granule
	Molecular Function	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		24 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 ETF1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP	27 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 NEK9 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		10277	3002
HPRD ID		11659	00476
Ensembl ID		ENSG00000130939	ENSG00000100453
Uniprot IDs		O95155	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		2KRE 3L1X 3L1Z 5O75	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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