UBE4B and ETF1

		UBE4B	ETF1
Description		ubiquitination factor E4B	eukaryotic translation termination factor 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol Translation Release Factor Complex
	Molecular Function	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding	RNA Binding Translation Release Factor Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translational Termination Regulation Of Translational Termination Protein Methylation
Pathways			Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		24 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 ETF1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP	11 interacting genes: BYSL CSF2 GSPT1 GSPT2 KEAP1 LIG4 MYOZ2 OGT PPP2CA UBE4B WFDC1
Entrez ID		10277	2107
HPRD ID		11659	02616
Ensembl ID		ENSG00000130939	ENSG00000120705
Uniprot IDs		O95155	B7Z7P8 P62495
PDB IDs		2KRE 3L1X 3L1Z 5O75	1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME
Enriched GO Terms of Interacting Partners?
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