NDEL1 and PAFAH1B1

Data Source:
HPRD (two hybrid, in vivo)

		NDEL1	PAFAH1B1
Description		nudE neurodevelopment protein 1 like 1	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Centrosome Spindle Cytosol Kinesin Complex Microtubule Synaptic Vesicle Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Central Region Of Growth Cone Axon Cytoplasm	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cell Leading Edge Motile Cilium Nuclear Membrane Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding Oligopeptidase Activity	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Activation Of GTPase Activity Positive Regulation Of Ruffle Assembly Neuron Projection Extension Regulation Of Microtubule Motor Activity	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Acrosome Assembly Neuron Migration Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Regulation Of G2/M Transition Of Mitotic Cell Cycle Lipid Catabolic Process Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Reelin-mediated Signaling Pathway Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Cell Division Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS			Adverse response to drug ( 30420678) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		88 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNC1I1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 KRT40 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	22 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		81565	5048
HPRD ID		06340	03329
Ensembl ID		ENSG00000166579	ENSG00000007168
Uniprot IDs		A6NIZ0 Q9GZM8	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		2V66
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?