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USP7 and UBE2D3
Data Source:
BioGRID
(enzymatic study)
USP7
UBE2D3
Description
ubiquitin specific peptidase 7
ubiquitin conjugating enzyme E2 D3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Exosome
Molecular Function
P53 Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
Ubiquitinyl Hydrolase Activity
Lys48-specific Deubiquitinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Regulation Of Gluconeogenesis
Transcription-coupled Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Multicellular Organism Development
Maintenance Of DNA Methylation
Viral Process
Protein Ubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Protein Stability
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Regulation Of Circadian Rhythm
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Positive Regulation Of DNA Demethylation
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
DNA Repair
Cellular Protein Modification Process
Protein Monoubiquitination
Protein Targeting To Peroxisome
Apoptotic Process
Protein Ubiquitination
BMP Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Cadmium Ion
Cellular Response To Mercury Ion
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Asthma and attention deficit hyperactivity disorder (
31619474
)
Diastolic blood pressure (
30224653
)
Interacting Genes
103 interacting genes:
ABRAXAS2
ACD
ANKS1A
ANXA1
ARNT2
ATXN1
AXIN1
BCOR
BEND5
CBX8
CLSPN
CREB3L3
CRY1
CSNK2A1
DAXX
DCTPP1
DNAJA3
DNMT3A
ERCC6
EWSR1
FOXN2
GATA1
H2AC20
H2BU1
HECW1
HERPUD1
HIF1A
HTRA2
HUWE1
IFNAR1
KAT5
KDM1A
KLHL8
LINC02582
MAGEE1
MAL
MARCHF7
MCMBP
MDM2
MDM4
MYC
MYD88
NECAB2
NOTCH1
OTUD4
PCGF2
PEG3
PEPD
PHF8
PHLDB2
PICK1
PLA2G2A
PLEKHO1
PLK1
PPARG
PPL
PSMD4
PTEN
RAD18
RADIL
RARA
RB1
RBCK1
RELA
RFFL
RNF168
RNF220
SIRT7
SMAD3
SNCA
SUMO2
SYVN1
TANK
TBCB
TFIP11
TMPO
TP53
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
UBA52
UBC
UBE2D3
UBE2E1
UBE2S
USP21
USP28
VCP
WWP2
XPC
ZMYND8
ZNF423
ZNF76
224 interacting genes:
AMBRA1
AMFR
ANAPC11
AREL1
ARIH1
ARIH2
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRCA1
CADPS2
CBL
CBLC
CHFR
CNOT4
CSNK2A1
CUL4B
DBN1
DCUN1D1
DDX58
DTX1
DTX2
DTX3
DTX3L
DVL2
DZIP3
EPS15
ERGIC3
ESR1
F12
FBXL12
FBXL17
FBXL2
FBXO2
FBXO25
FBXO7
FBXW11
FBXW8
FOCAD
FZR1
H2AC4
H3C1
H4C1
HDAC6
HECTD1
HECW1
HECW2
HERC1
HERC2
HUWE1
IKBKG
ITCH
KAT2B
KDM1B
LRSAM1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF7
MARCHF8
MAST1
MDM2
MDM4
MEX3B
MEX3C
MGRN1
MIB1
MID1
MID2
MKRN1
MKRN3
MSL1
MSL2
MUL1
MYCBP2
MYLIP
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NHLRC1
NOSIP
OTUB1
PCGF1
PCGF2
PCGF3
PCGF5
PCGF6
PCNA
PDCD5
PELI1
PER2
PJA1
PJA2
POLL
POLM
PRPF19
PTEN
RABGEF1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF185
RNF19B
RNF2
RNF216
RNF220
RNF25
RNF26
RNF31
RNF38
RNF4
RNF41
RNF43
RNF5
RNF8
RNFT1
RPLP1
RSPRY1
SAT1
SH3RF1
SHOC2
SIAH1
SIAH2
SMURF1
SMURF2
SOX2
SQSTM1
ST7
STAM2
STAU1
STK25
STUB1
SYVN1
TMEM129
TOPORS
TP53
TP73
TRAF6
TRAIP
TRIM10
TRIM17
TRIM2
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM58
TRIM62
TRIM63
TRIM68
TRIM69
TRIM7
TRIM72
TRIM8
TUBA1A
UBA1
UBA6
UBASH3B
UBE2O
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR5
UBTD1
UFM1
UHRF1
USP7
UVSSA
WBP2
WSB1
WWP1
WWP2
XIAP
XPNPEP1
ZNRF1
ZNRF2
ZNRF4
Entrez ID
7874
7323
HPRD ID
03950
04269
Ensembl ID
ENSG00000187555
ENSG00000109332
Uniprot IDs
B7Z855
B7ZAX6
Q6U8A4
Q93009
A0A024RDH2
D6RAH7
P61077
PDB IDs
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
1X23
2FUH
3L1Z
3RPG
3UGB
4BVU
4R8P
4S3O
5EGG
5IFR
6CP0
6T7F
Enriched GO Terms of Interacting Partners
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