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USP7 and CRY1
Data Source:
BioGRID
(enzymatic study)
USP7
CRY1
Description
ubiquitin specific peptidase 7
cryptochrome circadian regulator 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Nucleus
Cytoplasm
Mitochondrion
Molecular Function
P53 Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
Ubiquitinyl Hydrolase Activity
Lys48-specific Deubiquitinase Activity
DNA Binding
Double-stranded DNA Binding
Deoxyribodipyrimidine Photo-lyase Activity
DNA (6-4) Photolyase Activity
Protein Binding
Blue Light Photoreceptor Activity
Protein Kinase Binding
Phosphatase Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
E-box Binding
FAD Binding
Biological Process
Regulation Of Gluconeogenesis
Transcription-coupled Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Multicellular Organism Development
Maintenance Of DNA Methylation
Viral Process
Protein Ubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Protein Stability
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Regulation Of Circadian Rhythm
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Positive Regulation Of DNA Demethylation
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
DNA Damage Induced Protein Phosphorylation
Circadian Rhythm
Response To Light Stimulus
Blue Light Signaling Pathway
Response To Activity
Protein-chromophore Linkage
Lipid Storage
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Glucagon
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Gluconeogenesis
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Glucocorticoid Secretion
Pathways
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Circadian Clock
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Morning person (
30696823
)
Interacting Genes
103 interacting genes:
ABRAXAS2
ACD
ANKS1A
ANXA1
ARNT2
ATXN1
AXIN1
BCOR
BEND5
CBX8
CLSPN
CREB3L3
CRY1
CSNK2A1
DAXX
DCTPP1
DNAJA3
DNMT3A
ERCC6
EWSR1
FOXN2
GATA1
H2AC20
H2BU1
HECW1
HERPUD1
HIF1A
HTRA2
HUWE1
IFNAR1
KAT5
KDM1A
KLHL8
LINC02582
MAGEE1
MAL
MARCHF7
MCMBP
MDM2
MDM4
MYC
MYD88
NECAB2
NOTCH1
OTUD4
PCGF2
PEG3
PEPD
PHF8
PHLDB2
PICK1
PLA2G2A
PLEKHO1
PLK1
PPARG
PPL
PSMD4
PTEN
RAD18
RADIL
RARA
RB1
RBCK1
RELA
RFFL
RNF168
RNF220
SIRT7
SMAD3
SNCA
SUMO2
SYVN1
TANK
TBCB
TFIP11
TMPO
TP53
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
UBA52
UBC
UBE2D3
UBE2E1
UBE2S
USP21
USP28
VCP
WWP2
XPC
ZMYND8
ZNF423
ZNF76
26 interacting genes:
ARIH1
ARNTL
BHLHE41
CBLB
CLOCK
CSNK1E
DELEC1
FBXL3
GRN
KRTAP4-12
LTBP4
MDFI
NPAS2
NR1D2
PER1
PER2
PER3
PLSCR1
PPP2R1B
PPP2R5D
PPP2R5E
SNRPD3
TIMELESS
TRAF2
USP2
USP7
Entrez ID
7874
1407
HPRD ID
03950
09050
Ensembl ID
ENSG00000187555
ENSG00000008405
Uniprot IDs
B7Z855
B7ZAX6
Q6U8A4
Q93009
A2I2P0
Q16526
PDB IDs
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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