Wiki-Pi
About
Search
Browse
People
Updates
Search
UBE2D3 and HUWE1
Data Source:
BioGRID
(pull down)
UBE2D3
HUWE1
Description
ubiquitin conjugating enzyme E2 D3
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Exosome
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
DNA Repair
Cellular Protein Modification Process
Protein Monoubiquitination
Protein Targeting To Peroxisome
Apoptotic Process
Protein Ubiquitination
BMP Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Cadmium Ion
Cellular Response To Mercury Ion
Positive Regulation Of Protein Targeting To Mitochondrion
Protein Polyubiquitination
Base-excision Repair
Protein Monoubiquitination
Golgi Organization
Negative Regulation Of Mitochondrial Fusion
Protein Ubiquitination
Histone Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Positive Regulation Of Protein Catabolic Process
Membrane Fusion
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Asthma and attention deficit hyperactivity disorder (
31619474
)
Diastolic blood pressure (
30224653
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Educational attainment (years of education) (
30038396
)
Interacting Genes
224 interacting genes:
AMBRA1
AMFR
ANAPC11
AREL1
ARIH1
ARIH2
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRCA1
CADPS2
CBL
CBLC
CHFR
CNOT4
CSNK2A1
CUL4B
DBN1
DCUN1D1
DDX58
DTX1
DTX2
DTX3
DTX3L
DVL2
DZIP3
EPS15
ERGIC3
ESR1
F12
FBXL12
FBXL17
FBXL2
FBXO2
FBXO25
FBXO7
FBXW11
FBXW8
FOCAD
FZR1
H2AC4
H3C1
H4C1
HDAC6
HECTD1
HECW1
HECW2
HERC1
HERC2
HUWE1
IKBKG
ITCH
KAT2B
KDM1B
LRSAM1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF7
MARCHF8
MAST1
MDM2
MDM4
MEX3B
MEX3C
MGRN1
MIB1
MID1
MID2
MKRN1
MKRN3
MSL1
MSL2
MUL1
MYCBP2
MYLIP
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NHLRC1
NOSIP
OTUB1
PCGF1
PCGF2
PCGF3
PCGF5
PCGF6
PCNA
PDCD5
PELI1
PER2
PJA1
PJA2
POLL
POLM
PRPF19
PTEN
RABGEF1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF185
RNF19B
RNF2
RNF216
RNF220
RNF25
RNF26
RNF31
RNF38
RNF4
RNF41
RNF43
RNF5
RNF8
RNFT1
RPLP1
RSPRY1
SAT1
SH3RF1
SHOC2
SIAH1
SIAH2
SMURF1
SMURF2
SOX2
SQSTM1
ST7
STAM2
STAU1
STK25
STUB1
SYVN1
TMEM129
TOPORS
TP53
TP73
TRAF6
TRAIP
TRIM10
TRIM17
TRIM2
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM58
TRIM62
TRIM63
TRIM68
TRIM69
TRIM7
TRIM72
TRIM8
TUBA1A
UBA1
UBA6
UBASH3B
UBE2O
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR5
UBTD1
UFM1
UHRF1
USP7
UVSSA
WBP2
WSB1
WWP1
WWP2
XIAP
XPNPEP1
ZNRF1
ZNRF2
ZNRF4
36 interacting genes:
ABL1
ATOH1
CALM1
CCL1
CDKN2A
CTNNB1
CUL4B
ERG
H2AX
HDAC2
HSPB1
LAPTM5
MCL1
MYCN
PCNA
PIAS2
POLB
POLL
PPP5C
RBBP7
RNF11
SMAD2
SMAD9
SUMO2
TBP
TNS2
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2L3
USP4
USP7
WBP2
Entrez ID
7323
10075
HPRD ID
04269
06608
Ensembl ID
ENSG00000109332
ENSG00000086758
Uniprot IDs
A0A024RDH2
D6RAH7
P61077
A0A024R9W5
Q7Z6Z7
PDB IDs
1X23
2FUH
3L1Z
3RPG
3UGB
4BVU
4R8P
4S3O
5EGG
5IFR
6CP0
6T7F
2EKK
2MUL
3G1N
3H1D
5C6H
5LP8
6FYH
6MIW
6PFL
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?