ELOVL4 and VAPB

Data Source:
BioGRID (two hybrid)

		ELOVL4	VAPB
Description		ELOVL fatty acid elongase 4	VAMP associated protein B and C
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process	Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Process Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Sphingolipid de novo biosynthesis
Drugs		Omega-3-carboxylic acids
Diseases		Stargardt disease (STGD); Fundus flavimaculatus	Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121) Partial epilepsies ( 20522523)
Interacting Genes		95 interacting genes: ADGRE2 ANKRD46 APOL3 ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 ITGAM JAGN1 LEPROTL1 LHFPL5 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SNORC STX3 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM199 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB YIF1A YIPF6 ZDHHC21 ZFPL1	41 interacting genes: AIG1 AQP2 AQP6 CD79A CYB561 CYBRD1 EBAG9 EBP ELOVL4 EMD FAM174A GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MTNR1A OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC22A1 SLC35C2 STX1A STX2 STX4 STX5 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15
Entrez ID		6785	9217
HPRD ID		05697	09300
Ensembl ID		ENSG00000118402	ENSG00000124164
Uniprot IDs		Q9GZR5	O95292 Q53XM7
PDB IDs			2MDK 3IKK
Enriched GO Terms of Interacting Partners?
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