VAPB and CYBRD1

Data Source:
BioGRID (two hybrid)

		VAPB	CYBRD1
Description		VAMP associated protein B and C	cytochrome b reductase 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Ferric-chelate Reductase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Process Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Cellular Iron Ion Homeostasis Response To Iron Ion
Pathways		Sphingolipid de novo biosynthesis	Iron uptake and transport
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Pulse pressure ( 30224653)
Interacting Genes		41 interacting genes: AIG1 AQP2 AQP6 CD79A CYB561 CYBRD1 EBAG9 EBP ELOVL4 EMD FAM174A GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MTNR1A OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC22A1 SLC35C2 STX1A STX2 STX4 STX5 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	20 interacting genes: CREB3 FKBP8 GIMAP5 GOSR2 HMOX1 LMNA LPAR3 NEDD4L PLP2 RABAC1 SEC22A SERP1 SERP2 STX4 STX7 TMEM120A TMEM65 VAPA VAPB ZFPL1
Entrez ID		9217	79901
HPRD ID		09300	05764
Ensembl ID		ENSG00000124164	ENSG00000071967
Uniprot IDs		O95292 Q53XM7	Q53TN4
PDB IDs		2MDK 3IKK	5ZLE 5ZLG
Enriched GO Terms of Interacting Partners?
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