VAPB and OSBPL2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		VAPB	OSBPL2
Description		VAMP associated protein B and C	oxysterol binding protein like 2
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Lipid Droplet Cytosol Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Transfer Activity Sterol Transporter Activity Cholesterol Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Process Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Bile Acid Biosynthetic Process Plasma Membrane Organization Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization Intermembrane Lipid Transfer
Pathways		Sphingolipid de novo biosynthesis	Synthesis of bile acids and bile salts
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lumbar spine bone mineral density ( 29499414) Nicotine dependence symptom count ( 25555482) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		41 interacting genes: AIG1 AQP2 AQP6 CD79A CYB561 CYBRD1 EBAG9 EBP ELOVL4 EMD FAM174A GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MTNR1A OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC22A1 SLC35C2 STX1A STX2 STX4 STX5 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	2 interacting genes: SNRPF VAPB
Entrez ID		9217	9885
HPRD ID		09300	09473
Ensembl ID		ENSG00000124164	ENSG00000130703
Uniprot IDs		O95292 Q53XM7	B4DKJ8 E7ET92 Q9H1P3
PDB IDs		2MDK 3IKK	5ZM8
Enriched GO Terms of Interacting Partners?
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