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SRF and FHL1
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
SRF
FHL1
Description
serum response factor
four and a half LIM domains 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Chromatin DNA Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
Sequence-specific Double-stranded DNA Binding
Molecular_function
Protein Binding
Ion Channel Binding
Metal Ion Binding
Biological Process
Branching Involved In Blood Vessel Morphogenesis
Response To Hypoxia
Mesoderm Formation
Neuron Migration
Trophectodermal Cell Differentiation
Heart Looping
Morphogenesis Of An Epithelial Sheet
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Cell-matrix Adhesion
Heart Development
Long-term Memory
Negative Regulation Of Cell Population Proliferation
Associative Learning
Response To Toxic Substance
Response To Hormone
Epithelial Structure Maintenance
Positive Regulation Of Transcription Via Serum Response Element Binding
Hippocampus Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Platelet Activation
Platelet Formation
Negative Regulation Of Cell Migration
Thyroid Gland Development
Neuron Projection Development
Regulation Of Water Loss Via Skin
Response To Cytokine
Megakaryocyte Development
Dorsal Aorta Morphogenesis
Stress Fiber Assembly
Skin Morphogenesis
Positive Thymic T Cell Selection
Sarcomere Organization
Positive Regulation Of Cell Differentiation
Positive Regulation Of Axon Extension
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of Transcription By Glucose
Muscle Cell Cellular Homeostasis
Thymus Development
Developmental Growth
Neuron Development
Erythrocyte Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Filopodium Assembly
Cardiac Myofibril Assembly
Angiogenesis Involved In Wound Healing
Hematopoietic Stem Cell Differentiation
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Long-term Synaptic Depression
Face Development
Heart Trabecula Formation
Lung Morphogenesis
Bronchus Cartilage Development
Trachea Cartilage Development
Cardiac Vascular Smooth Muscle Cell Differentiation
Eyelid Development In Camera-type Eye
Lung Smooth Muscle Development
Bicellular Tight Junction Assembly
Cellular Response To Glucose Stimulus
Primitive Streak Formation
Epithelial Cell-cell Adhesion
Cellular Senescence
Negative Regulation Of Amyloid-beta Clearance
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Membrane Depolarization
Muscle Organ Development
Animal Organ Morphogenesis
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of Potassium Ion Transport
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
RHO GTPases Activate Formins
NGF-stimulated transcription
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
X-linked myopathy with postural muscle atrophy (XMPMA)
Reducing body myopathy (RBM)
Scapuloperoneal myopathy (SPM)
Emery-Dreifuss muscular dystrophy
GWAS
Interacting Genes
71 interacting genes:
ALDH3A1
ATF6
BARX2
CAMK2A
CASP3
CASP6
CASP7
CASP8
CASP9
CD63
CEBPB
CIRBP
CREB1
CREBBP
CRIP2
CSNK2A1
ELK1
ELK4
ETV4
FHL1
FHL2
FHL3
FHL5
FLI1
FOXG1
FOXK1
GATA4
GTF2F1
GTF2I
HDAC4
HMGA1
HOPX
KAT5
KDM6A
MAPKAPK2
MINPP1
MRTFA
MRTFB
MYOCD
MYOD1
MYOG
NCOA1
NCOA6
NCOR2
NFKB1
NFYA
NKX2-3
NKX2-5
NKX3-1
OGT
PML
PRKDC
PRRX1
PYCARD
RARA
REL
RELA
RPS6KA1
RXRA
RXRG
SHBG
SP1
SRC
SRFBP1
SSRP1
TCF3
TEAD1
TRIM63
TRIP4
UBE2I
ZIC3
32 interacting genes:
AKAP12
CBX4
CDC25C
CHEK2
CLMN
CSRP3
DBN1
DEAF1
DOCK9
EED
ENO1
FHL2
HES1
HIVEP3
IGFBP5
LAMA4
MACF1
MYBPC1
NFIL3
PAX7
PDE4DIP
PDLIM3
PRNP
RBPJ
RING1
SRF
SRPK1
TTN
TXNIP
USP15
YWHAE
ZBTB40
Entrez ID
6722
2273
HPRD ID
02788
02157
Ensembl ID
ENSG00000112658
ENSG00000022267
Uniprot IDs
A0A024RD16
B4DU24
P11831
B7Z9A1
Q13642
Q5JXI2
PDB IDs
1HBX
1K6O
1SRS
1X63
2CUP
2CUR
2EGQ
Enriched GO Terms of Interacting Partners
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