FHL1 and AKAP12

Data Source:
BioGRID (two hybrid, two hybrid)

		FHL1	AKAP12
Description		four and a half LIM domains 1	A-kinase anchoring protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Neuronal Cell Body Schaffer Collateral - CA1 Synapse
	Molecular Function	Molecular_function Protein Binding Ion Channel Binding Metal Ion Binding	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Protein Kinase A Signaling Response To Lipopolysaccharide Hepatic Stellate Cell Activation Negative Regulation Of Vascular Permeability Modulation Of Chemical Synaptic Transmission Response To Electrical Stimulus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Regulation Of Protein Kinase C Signaling Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GWAS			Alzheimer's disease progression score ( 29860282) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Chronic myeloid leukemia ( 21540461) Coronary artery disease ( 29212778) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Delirium ( 29631748) Heel bone mineral density ( 30598549) Nevus count or cutaneous melanoma ( 32341527) Refractive error ( 32231278) Type 2 diabetes ( 25760438) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: AKAP12 CBX4 CDC25C CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40	8 interacting genes: ADRB2 EGFR ERBB2 FHL1 GRK2 PRKAR2A PRKCA PTEN
Entrez ID		2273	9590
HPRD ID		02157	05263
Ensembl ID		ENSG00000022267	ENSG00000131016
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	Q02952 Q86TJ9
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?
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