BLMH and ECSIT

Data Source:
BioGRID (two hybrid)

		BLMH	ECSIT
Description		bleomycin hydrolase	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	Protein Binding
	Biological Process	Protein Polyubiquitination Proteolysis Response To Toxic Substance Response To Drug Homocysteine Catabolic Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		20 interacting genes: AP1M2 APP CDC42 CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NUDT12 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		642	51295
HPRD ID		03870	12225
Ensembl ID		ENSG00000108578	ENSG00000130159
Uniprot IDs		Q13867	Q9BQ95
PDB IDs		1CB5 2CB5
Enriched GO Terms of Interacting Partners?
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