BLMH and CYP2C8

Data Source:
BioGRID (two hybrid)

		BLMH	CYP2C8
Description		bleomycin hydrolase	cytochrome P450 family 2 subfamily C member 8
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Protein Polyubiquitination Proteolysis Response To Toxic Substance Response To Drug Homocysteine Catabolic Process	Lipid Hydroxylation Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Retinol Metabolic Process Retinoic Acid Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs
Drugs			Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS			Blood metabolite levels ( 24816252) Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		20 interacting genes: AP1M2 APP CDC42 CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NUDT12 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I	12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32
Entrez ID		642	1558
HPRD ID		03870	03083
Ensembl ID		ENSG00000108578	ENSG00000138115
Uniprot IDs		Q13867	B7Z1F5 P10632
PDB IDs		1CB5 2CB5	1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?
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