EPS15L1 and EPN1

Data Source:
HPRD (in vitro)

		EPS15L1	EPN1
Description		epidermal growth factor receptor pathway substrate 15 like 1	epsin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Clathrin Coat Of Coated Pit	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding Cadherin Binding	Protein Binding Phospholipid Binding Clathrin Binding
	Biological Process	Endocytosis Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Basophil count ( 32888494) Body size at age 10 ( 32376654) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 22190364 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) White blood cell count ( 32888494 27863252 21738480) White matter integrity ( 23218918)	Major depressive disorder ( 23377640)
Interacting Genes		15 interacting genes: AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 ITSN1 ITSN2 LRRC7 NDC80 SGIP1 STON2 TRAPPC2 TRAPPC2B UBC	25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		58513	29924
HPRD ID		09445	06270
Ensembl ID		ENSG00000127527	ENSG00000063245
Uniprot IDs		A0A024R7G6 Q9UBC2	A0A024R4S1 Q9Y6I3
PDB IDs			1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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