PIH1D1 and FARP1

Data Source:
BioGRID (two hybrid)

		PIH1D1	FARP1
Description		PIH1 domain containing 1	FERM, ARH/RhoGEF and pleckstrin domain protein 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex Ribonucleoprotein Complex	Cytosol Cytoskeleton Filopodium Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Box C/D SnoRNP Assembly RNA Polymerase I Preinitiation Complex Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly SnoRNA Localization Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Synapse Assembly Negative Regulation Of Phosphatase Activity Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Brain structure ( 20171287) Clozapine-induced agranulocytosis ( 25187353) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 33020668) Educational attainment ( 25201988) General factor of neuroticism ( 30867560) Household income ( 31844048) Household income (MTAG) ( 31844048) Ischemic stroke (large artery atherosclerosis) ( 29531354) Mood instability ( 31168069) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Response to amphetamines ( 22952603) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		20 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM LRCH3 MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 RPAP2 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4	1 interacting genes: PIH1D1
Entrez ID		55011	10160
HPRD ID		07938	16006
Ensembl ID		ENSG00000104872	ENSG00000152767
Uniprot IDs		Q9NWS0	A0A2X0TVY0 C9JME2 Q9Y4F1
PDB IDs		4PSF 4PSI 6GXZ	4H6Y
Enriched GO Terms of Interacting Partners?
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