PIH1D1 and CA4

Data Source:
BioGRID (two hybrid)

		PIH1D1	CA4
Description		PIH1 domain containing 1	carbonic anhydrase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex Ribonucleoprotein Complex	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Box C/D SnoRNP Assembly RNA Polymerase I Preinitiation Complex Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly SnoRNA Localization Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	One-carbon Metabolic Process Bicarbonate Transport
Pathways			Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs			Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases			Retinitis pigmentosa (RP)
GWAS
Interacting Genes		20 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM LRCH3 MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 RPAP2 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4	5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		55011	762
HPRD ID		07938	00261
Ensembl ID		ENSG00000104872	ENSG00000167434
Uniprot IDs		Q9NWS0	P22748
PDB IDs		4PSF 4PSI 6GXZ	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
Enriched GO Terms of Interacting Partners?
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