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CTSA and THAP4
Data Source:
BioGRID
(two hybrid)
CTSA
THAP4
Description
cathepsin A
THAP domain containing 4
Image
GO Annotations
Cellular Component
Extracellular Region
Lysosome
Endoplasmic Reticulum
Membrane
Azurophil Granule Lumen
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Lumenal Side Of Lysosomal Membrane
Cellular_component
Molecular Function
Carboxypeptidase Activity
Serine-type Carboxypeptidase Activity
Enzyme Activator Activity
DNA Binding
Protein Binding
Heme Binding
Identical Protein Binding
Metal Ion Binding
Peroxynitrite Isomerase Activity
Nitric Oxide Binding
Biological Process
Proteolysis
Glycosphingolipid Metabolic Process
Intracellular Protein Transport
Regulation Of Protein Stability
Neutrophil Degranulation
Regulation Of Catalytic Activity
Regulation Of Chaperone-mediated Autophagy
Negative Regulation Of Chaperone-mediated Autophagy
Tyrosine Metabolic Process
Nitrate Metabolic Process
Pathways
Glycosphingolipid metabolism
MHC class II antigen presentation
Sialic acid metabolism
Defective NEU1 causes sialidosis
Neutrophil degranulation
Drugs
Diseases
Galactosialidosis
GWAS
Brain structure (
20171287
)
Platelet count (
32888494
)
Prostate cancer (
23535732
)
Thyroid stimulating hormone levels (
32769997
)
Interacting Genes
45 interacting genes:
AHNAK2
AQP2
AQP6
ARL13B
ASPH
BSND
CD79A
COQ9
CPLX4
CREB3L1
CSPG5
ERGIC3
FAM209A
FKBP7
FNDC9
GLB1
GORAB
HIBADH
LAMP2
LMNA
LTB4R2
MFSD14B
MGST3
MUC1
MYG1
NEU1
PSCA
REEP4
RHBDD1
RNF122
SAR1A
SGMS2
SIGLEC12
SLC18A1
SLC30A2
SPN
SSMEM1
STX2
THAP4
TMEM139
TMEM154
TMEM237
TMEM31
TMEM35A
TMX2
42 interacting genes:
AGTRAP
AIG1
AMD1
ANKRD46
APP
BSND
CACNG1
CD81
CLCA4
CMTM5
CMTM7
COL4A5
CPNE2
CTSA
CYP4F2
DGAT2L6
FKBP7
GIMAP1
GPR37L1
IGFBP5
LAT
LPAR3
MAL2
MAPK6
MOB4
MS4A1
NDRG4
PLP2
RMDN2
RTP2
SCAMP1
SLC30A8
SYP
TMEM107
TMEM60
TMEM86A
TMEM86B
TNFRSF10D
TPD52
TRIM54
TTPA
YIPF6
Entrez ID
5476
51078
HPRD ID
02020
11630
Ensembl ID
ENSG00000064601
ENSG00000176946
Uniprot IDs
B4E324
P10619
X6R5C5
X6R8A1
Q8WY91
PDB IDs
1IVY
3BP4
3BP7
3BXN
4AZ0
4AZ3
4CI9
4CIA
4CIB
4MWS
4MWT
6WIA
3IA8
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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