THAP4 and CTSA

Data Source:
BioGRID (two hybrid)

		THAP4	CTSA
Description		THAP domain containing 4	cathepsin A
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GO Annotations	Cellular Component	Cellular_component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane
	Molecular Function	DNA Binding Protein Binding Heme Binding Identical Protein Binding Metal Ion Binding Peroxynitrite Isomerase Activity Nitric Oxide Binding	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Tyrosine Metabolic Process Nitrate Metabolic Process	Proteolysis Glycosphingolipid Metabolic Process Intracellular Protein Transport Regulation Of Protein Stability Neutrophil Degranulation Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy
Pathways			Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs
Diseases			Galactosialidosis
GWAS		Brain structure ( 20171287) Platelet count ( 32888494) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		42 interacting genes: AGTRAP AIG1 AMD1 ANKRD46 APP BSND CACNG1 CD81 CLCA4 CMTM5 CMTM7 COL4A5 CPNE2 CTSA CYP4F2 DGAT2L6 FKBP7 GIMAP1 GPR37L1 IGFBP5 LAT LPAR3 MAL2 MAPK6 MOB4 MS4A1 NDRG4 PLP2 RMDN2 RTP2 SCAMP1 SLC30A8 SYP TMEM107 TMEM60 TMEM86A TMEM86B TNFRSF10D TPD52 TRIM54 TTPA YIPF6	45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2
Entrez ID		51078	5476
HPRD ID		11630	02020
Ensembl ID		ENSG00000176946	ENSG00000064601
Uniprot IDs		Q8WY91	B4E324 P10619 X6R5C5 X6R8A1
PDB IDs		3IA8	1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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