TBC1D7 and MMADHC

Data Source:
BioGRID (two hybrid)

		TBC1D7	MMADHC
Description		TBC1 domain family member 7	metabolism of cobalamin associated D
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GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle Ciliary Basal Body	Cytoplasm Mitochondrion Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly	Cobalamin Metabolic Process
Pathways		TBC/RABGAPs	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Drugs
Diseases			Methylmalonic aciduria (MMA)
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)	Daytime sleep phenotypes ( 27126917) Liver enzyme levels (alanine transaminase) ( 24124411) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	6 interacting genes: CINP CREB5 MMACHC POU4F2 PRNP TBC1D7
Entrez ID		51256	27249
HPRD ID		18165	10781
Ensembl ID		ENSG00000145979	ENSG00000168288
Uniprot IDs		A0A024QZX0 A0A024R011 Q5JPB9 Q9P0N9 U3KPY5	Q9H3L0
PDB IDs		3QWL 4Z6Y 5EJC 5ULO	5CUZ 5CV0 6X8Z
Enriched GO Terms of Interacting Partners?
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