TBC1D7 and LNX2

Data Source:
BioGRID (two hybrid)

		TBC1D7	LNX2
Description		TBC1 domain family member 7	ligand of numb-protein X 2
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GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly
Pathways		TBC/RABGAPs
Drugs
Diseases
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)	Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494 27863252) Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494 27863252) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	89 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		51256	222484
HPRD ID		18165	10042
Ensembl ID		ENSG00000145979	ENSG00000139517
Uniprot IDs		A0A024QZX0 A0A024R011 Q5JPB9 Q9P0N9 U3KPY5	Q8N448
PDB IDs		3QWL 4Z6Y 5EJC 5ULO	2VWR 5DIN 5E11 5E1Y 5E21 5E22
Enriched GO Terms of Interacting Partners?
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