HSD17B11 and STX7

Data Source:
BioGRID (two hybrid)

		HSD17B11	STX7
Description		hydroxysteroid 17-beta dehydrogenase 11	syntaxin 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Immunological Synapse Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Endocytic Vesicle SNARE Complex Early Endosome Membrane Vesicle Azurophil Granule Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Tertiary Granule
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Estrogen Biosynthetic Process Androgen Catabolic Process	Positive Regulation Of T Cell Mediated Cytotoxicity Intracellular Protein Transport Vesicle Fusion Vesicle Docking Organelle Localization Organelle Assembly Positive Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Plasma Membrane
Pathways		Estrogen biosynthesis
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		59 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LNPEP LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SEC22B SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX5 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VAPA VEZT YIF1A YIPF6	54 interacting genes: ANKS6 AQP6 ARL13B CERS4 CISD2 CREB3 CREB3L1 CYBRD1 DNAJC5 EBP ELOVL5 ENTPD2 FAM174A FAM210B FKBP7 GJC3 HSD17B11 HSD17B13 JAGN1 LIME1 LMNA LSMEM2 MAPK6 MFF MGST3 MRM1 MTUS1 NAPA REEP1 RETREG3 RIC3 SAR1A SLC10A1 SLC10A6 SNAP29 STX1A STX2 STX4 STX6 STX8 TM4SF19 TMEM205 TMEM241 TMEM267 TMEM80 TMPRSS2 TMX2 VAMP7 VAMP8 VPS11 VPS16 VPS18 VTI1B ZFYVE27
Entrez ID		51170	8417
HPRD ID		10881	04449
Ensembl ID		ENSG00000198189	ENSG00000079950
Uniprot IDs		Q8NBQ5	O15400
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?
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