LTA and LTBR

Data Source:
HPRD (in vivo)

		LTA	LTBR
Description		lymphotoxin alpha	lymphotoxin beta receptor
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Apoptotic Process Immune Response Signal Transduction Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Etanercept
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Entrez ID		4049	4055
HPRD ID		01084	02988
Ensembl ID		ENSG00000226979	ENSG00000111321
Uniprot IDs		P01374 Q5STV3	P36941
PDB IDs		1TNR 4MXV 4MXW	1RF3 4MXW
Enriched GO Terms of Interacting Partners?
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