LTBR and LTB

Data Source:
HPRD (in vitro)

		LTBR	LTB
Description		lymphotoxin beta receptor	lymphotoxin beta
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Cellular_component Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Positive Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Skin Development Lymph Node Development
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)	AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Neonatal lupus ( 20662065) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	4 interacting genes: LTA LTBR TNFRSF1A TNFSF14
Entrez ID		4055	4050
HPRD ID		02988	02987
Ensembl ID		ENSG00000111321	ENSG00000227507
Uniprot IDs		P36941	Q06643 Q5STB2
PDB IDs		1RF3 4MXW	4MXW
Enriched GO Terms of Interacting Partners?
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