LTA and TMEM237

Data Source:
BioGRID (two hybrid)

		LTA	TMEM237
Description		lymphotoxin alpha	transmembrane protein 237
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Membrane Integral Component Of Membrane Photoreceptor Connecting Cilium Ciliary Transition Zone Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Regulation Of Wnt Signaling Pathway Cilium Assembly
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Etanercept
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	122 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 C4orf3 CBLIF CCDC167 CD53 CDS1 CFHR5 CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD5 MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1
Entrez ID		4049	65062
HPRD ID		01084	12448
Ensembl ID		ENSG00000226979	ENSG00000155755
Uniprot IDs		P01374 Q5STV3	Q96Q45
PDB IDs		1TNR 4MXV 4MXW
Enriched GO Terms of Interacting Partners?
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