LTA and UMOD

Data Source:
HPRD (in vitro)

		LTA	UMOD
Description		lymphotoxin alpha	uromodulin
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Spindle Pole Extracellular Space Endoplasmic Reticulum Golgi Lumen Cilium Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding IgG Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Allantoin Metabolic Process Organ Or Tissue Specific Immune Response Renal Water Homeostasis Glomerular Filtration Lipid Metabolic Process Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Autophagy Inflammatory Response Cellular Defense Response Endoplasmic Reticulum Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Excretion Negative Regulation Of Cell Population Proliferation RNA Splicing Response To Water Deprivation Peptidyl-threonine Phosphorylation Urate Catabolic Process Ubiquitin-dependent ERAD Pathway Cellular Phosphate Ion Homeostasis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Unfolded Protein Regulation Of Urine Volume Response To Drug Citric Acid Secretion Defense Response To Gram-negative Bacterium Regulation Of Protein Transport Chaperone-mediated Protein Folding Renal Sodium Ion Absorption Collecting Duct Development Juxtaglomerular Apparatus Development Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Protein Localization To Vacuole Apoptotic Signaling Pathway Creatinine Homeostasis Connective Tissue Replacement Neutrophil Migration
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Asparagine N-linked glycosylation
Drugs		Etanercept
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Chronic kidney disease ( 29124443 26831199 20383146) Chronic kidney disease and serum creatinine levels ( 20686651) Chronic kidney disease x type 2 diabetes interaction ( 32541925) Creatinine levels ( 29124443) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462 29124443 30604766) Femoral neck bone geometry ( 22087292) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate (cystatin C) ( 28452372) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in diabetics (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Hypertension ( 27618447 21082022) Hyperuricemia ( 29124443) Kidney function decline traits ( 25493955) Kidney stones ( 31729369) Medication use (calcium channel blockers) ( 31015401) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 29124443) Urate levels ( 31578528) Urinary uromodulin levels ( 24578125)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	3 interacting genes: LINC02582 LTA MMP8
Entrez ID		4049	7369
HPRD ID		01084	11771
Ensembl ID		ENSG00000226979	ENSG00000169344
Uniprot IDs		P01374 Q5STV3	P07911
PDB IDs		1TNR 4MXV 4MXW	4WRN 6TQK 6TQL 6ZS5 6ZYA
Enriched GO Terms of Interacting Partners?
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