LTA and LTB

Data Source:
HPRD (in vitro, in vivo)

		LTA	LTB
Description		lymphotoxin alpha	lymphotoxin beta
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Cellular_component Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Positive Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Skin Development Lymph Node Development
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Etanercept
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Neonatal lupus ( 20662065) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	4 interacting genes: LTA LTBR TNFRSF1A TNFSF14
Entrez ID		4049	4050
HPRD ID		01084	02987
Ensembl ID		ENSG00000226979	ENSG00000227507
Uniprot IDs		P01374 Q5STV3	Q06643 Q5STB2
PDB IDs		1TNR 4MXV 4MXW	4MXW
Enriched GO Terms of Interacting Partners?
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