KRT5 and KRT35

Data Source:
BioGRID (two hybrid)

		KRT5	KRT35
Description		keratin 5	keratin 35
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Anatomical Structure Morphogenesis Keratinization Cornification
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	87 interacting genes: ABI3 ATG9A BCAS2 C1orf109 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446
Entrez ID		3852	3886
HPRD ID		01010	04138
Ensembl ID		ENSG00000186081	ENSG00000197079
Uniprot IDs		P13647	Q92764
PDB IDs		3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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