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KRT5 and ALOX12
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(in vivo)
KRT5
ALOX12
Description
keratin 5
arachidonate 12-lipoxygenase, 12S type
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Intermediate Filament
Membrane
Keratin Filament
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Sarcolemma
Extracellular Exosome
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Scaffold Protein Binding
Arachidonate 12(S)-lipoxygenase Activity
Iron Ion Binding
Protein Binding
Linoleate 13S-lipoxygenase Activity
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Hepoxilin-epoxide Hydrolase Activity
Arachidonate 15-lipoxygenase Activity
Biological Process
Cytoskeleton Organization
Epidermis Development
Keratinization
Hemidesmosome Assembly
Cornification
Lipid Metabolic Process
Aging
Positive Regulation Of Gene Expression
Negative Regulation Of Muscle Cell Apoptotic Process
Arachidonic Acid Metabolic Process
Lipoxygenase Pathway
Fatty Acid Oxidation
Unsaturated Fatty Acid Metabolic Process
Lipid Oxidation
Superoxide Anion Generation
Long-chain Fatty Acid Biosynthetic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Linoleic Acid Metabolic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Hepoxilin Metabolic Process
Hepoxilin Biosynthetic Process
Positive Regulation Of Mitochondrial Depolarization
Establishment Of Skin Barrier
Cellular Response To Lipid
Negative Regulation Of Platelet Aggregation
Leukotriene A4 Metabolic Process
Positive Regulation Of Endothelial Tube Morphogenesis
Lipoxin Biosynthetic Process
Lipoxin A4 Biosynthetic Process
Lipoxin B4 Biosynthetic Process
Pathways
Type I hemidesmosome assembly
Keratinization
Formation of the cornified envelope
Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Synthesis of Lipoxins (LX)
Synthesis of 12-eicosatetraenoic acid derivatives
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPAn-6 SPMs
Biosynthesis of DPAn-3-derived maresins
Drugs
Zinc
Zinc acetate
Diseases
Dowling-Degos disease
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Basal cell carcinoma (
31174203
24403052
25855136
27539887
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
Non-melanoma skin cancer (
29739929
)
Squamous cell carcinoma (
31174203
)
Blood metabolite levels (
24816252
)
Mean platelet volume (
32888494
)
Interacting Genes
25 interacting genes:
ALOX12
ALOX12B
APC
DSP
DST
EVPL
INCA1
KIFC3
KRT1
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT27
KRT28
KRT31
KRT35
KRT38
KRT40
PKP2
TCHP
UBE3A
7 interacting genes:
ITGB4
KAT5
KRT5
KRT85
LMNA
PLA2G2A
TRIB1
Entrez ID
3852
239
HPRD ID
01010
01066
Ensembl ID
ENSG00000186081
ENSG00000108839
Uniprot IDs
P13647
P18054
PDB IDs
3TNU
6JFV
2ABU
3D3L
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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