KRT35 and CTSZ

Data Source:
BioGRID (two hybrid)

		KRT35	CTSZ
Description		keratin 35	cathepsin Z
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Cell Cortex Region Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Molecule Activity Protein Binding	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Anatomical Structure Morphogenesis Keratinization Cornification	Angiotensin Maturation Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Plasminogen Activation Negative Regulation Of Protein Binding Neutrophil Degranulation COPII Vesicle Coating Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Neuron Death
Pathways		Keratinization Formation of the cornified envelope	Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Monocyte count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		87 interacting genes: ABI3 ATG9A BCAS2 C1orf109 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446	21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2
Entrez ID		3886	1522
HPRD ID		04138	04410
Ensembl ID		ENSG00000197079	ENSG00000101160
Uniprot IDs		Q92764	Q9UBR2
PDB IDs			1DEU 1EF7
Enriched GO Terms of Interacting Partners?
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