ITGB7 and VCAM1

Data Source:
HPRD (in vitro)

		ITGB7	VCAM1
Description		integrin subunit beta 7	vascular cell adhesion molecule 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome	Podosome Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Integrin Binding Primary Amine Oxidase Activity Cell Adhesion Molecule Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Viral Entry Into Host Cell Regulation Of Immune Response Leukocyte Tethering Or Rolling T Cell Migration	Response To Hypoxia Acute Inflammatory Response Chronic Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Aging Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Cytokine-mediated Signaling Pathway Membrane To Membrane Docking B Cell Differentiation Extracellular Matrix Organization Response To Lipopolysaccharide Heterotypic Cell-cell Adhesion Response To Nicotine Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Regulation Of Immune Response Leukocyte Tethering Or Rolling Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion In Response To Extracellular Stimulus Cellular Response To Amyloid-beta
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		R1295 Vedolizumab	Ethanol Carvedilol Succinobucol Clove oil
Diseases
GWAS		Obesity-related traits ( 23251661)	Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 32888494) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1	13 interacting genes: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2
Entrez ID		3695	7412
HPRD ID		00948	01888
Ensembl ID		ENSG00000139626	ENSG00000162692
Uniprot IDs		P26010	P19320
PDB IDs		2BRQ 3V4P 3V4V	1IJ9 1VCA 1VSC
Enriched GO Terms of Interacting Partners?
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