ITGB7 and TLN1

Data Source:
HPRD (in vitro)

		ITGB7	TLN1
Description		integrin subunit beta 7	talin 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome	Ruffle Extracellular Region Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Viral Entry Into Host Cell Regulation Of Immune Response Leukocyte Tethering Or Rolling T Cell Migration	Platelet Degranulation Muscle Contraction Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		R1295 Vedolizumab
Diseases
GWAS		Obesity-related traits ( 23251661)	Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1	29 interacting genes: ABI1 ACTA1 AZIN2 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 SUMO2 TES TUBA1A VCL YWHAQ
Entrez ID		3695	7094
HPRD ID		00948	01726
Ensembl ID		ENSG00000139626	ENSG00000137076
Uniprot IDs		P26010	Q9Y490
PDB IDs		2BRQ 3V4P 3V4V	1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?
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