PLEKHB2 and DCUN1D1

Data Source:
BioGRID (two hybrid)

		PLEKHB2	DCUN1D1
Description		pleckstrin homology domain containing B2	defective in cullin neddylation 1 domain containing 1
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GO Annotations	Cellular Component	Integral Component Of Membrane Recycling Endosome Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Regulation Of Cell Differentiation	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways			Neddylation
Drugs
Diseases
GWAS			Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		49 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A	33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		55041	54165
HPRD ID		15144	12067
Ensembl ID		ENSG00000115762	ENSG00000043093
Uniprot IDs		A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	B4DM76 C9JVE2 Q96GG9
PDB IDs		3AJ4 3VIA	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W
Enriched GO Terms of Interacting Partners?
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