CRMP1 and ROCK1

Data Source:
HPRD (in vivo)

		CRMP1	ROCK1
Description		collapsin response mediator protein 1	Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations	Cellular Component	Nucleus Centrosome Spindle Cytosol Growth Cone Midbody Perikaryon	Golgi Membrane Ruffle Extracellular Region Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Lamellipodium Bleb Secretory Granule Lumen Amyloid-beta Complex
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Filamin Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Aspartic-type Endopeptidase Inhibitor Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance Negative Regulation Of Neuron Projection Development Negative Regulation Of Actin Filament Binding	Mitotic Cytokinesis Aortic Valve Morphogenesis Protein Phosphorylation Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Rho Protein Signal Transduction Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Phosphorylation Neutrophil Degranulation Positive Regulation Of MAPK Cascade Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Glomerular Visceral Epithelial Cell Migration Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		CRMPs in Sema3A signaling	Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation RHOBTB1 GTPase cycle Potential therapeutics for SARS
Drugs			Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil Y-27632 Ripasudil Netarsudil
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)
Interacting Genes		80 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24	36 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TPPP TRIM15 TSG101 UBE2T VIM
Entrez ID		1400	6093
HPRD ID		03913	03414
Ensembl ID		ENSG00000072832	ENSG00000067900
Uniprot IDs		B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1	Q13464
PDB IDs		4B3Z	1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W 7JOU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?