SERPINA3 and KLK2

Data Source:
HPRD (in vivo, in vitro)

		SERPINA3	KLK2
Description		serpin family A member 3	kallikrein related peptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Platelet degranulation Neutrophil degranulation	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		12	3817
HPRD ID		00120	01006
Ensembl ID		ENSG00000196136	ENSG00000167751
Uniprot IDs		A0A024R6P0 P01011	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE	4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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