KLK2 and SERPINA4

Data Source:
HPRD (in vitro)

		KLK2	SERPINA4
Description		kallikrein related peptidase 2	serpin family A member 4
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation	Platelet Degranulation Negative Regulation Of Endopeptidase Activity
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Platelet degranulation
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		3817	5267
HPRD ID		01006	01004
Ensembl ID		ENSG00000167751	ENSG00000100665
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	A0A024R6I9 P29622
PDB IDs		4NFE 4NFF	6F02
Enriched GO Terms of Interacting Partners?
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