KLK2

Description		kallikrein related peptidase 2
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GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Novel Interacting Genes		2 novel interacting genes: JADE2 MET
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		3817
HPRD ID		01006
Ensembl ID		ENSG00000167751
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs		4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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