SERPINA3 and CTRC

Data Source:
HPRD (in vivo)

		SERPINA3	CTRC
Description		serpin family A member 3	chymotrypsin C
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Proteolysis Cellular Calcium Ion Homeostasis Cobalamin Metabolic Process
Pathways		Platelet degranulation Neutrophil degranulation	Cobalamin (Cbl, vitamin B12) transport and metabolism
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 ST13 TEX37 UBC VGLL3
Entrez ID		12	11330
HPRD ID		00120	03242
Ensembl ID		ENSG00000196136	ENSG00000162438
Uniprot IDs		A0A024R6P0 P01011	Q99895
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE	4H4F
Enriched GO Terms of Interacting Partners?
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