SERPINA3 and HOXB1

Data Source:
HPRD (in vivo)

		SERPINA3	HOXB1
Description		serpin family A member 3	homeobox B1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Chromatin Nucleus
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways		Platelet degranulation Neutrophil degranulation	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Body mass index ( 26426971) Colorectal or endometrial cancer ( 26621817) Hemoglobin levels ( 32327693) Primary tooth development (number of teeth) ( 20195514) Waist circumference ( 28552196)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	10 interacting genes: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 RCHY1 SERPINA3 ZNF835
Entrez ID		12	3211
HPRD ID		00120	00855
Ensembl ID		ENSG00000196136	ENSG00000120094
Uniprot IDs		A0A024R6P0 P01011	P14653
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE	1B72
Enriched GO Terms of Interacting Partners?
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