TOMM20 and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 25591737)
8

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TOMM20	HSD17B10
Description		translocase of outer mitochondrial membrane 20	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated ER Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex
	Molecular Function	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Protein Targeting To Mitochondrion Response To Muscle Activity TRNA Import Into Mitochondrion Macroautophagy Protein Deubiquitination Protein Import Into Mitochondrial Matrix Mitochondrial Outer Membrane Translocase Complex Assembly Response To 3,3',5-triiodo-L-thyronine	Lipid Metabolic Process Mitochondrion Organization Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Oxidation-reduction Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases			2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		19 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PINK1 PRKN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		9804	3028
HPRD ID		03507	02223
Ensembl ID		ENSG00000173726	ENSG00000072506
Uniprot IDs		A0A024R3W2 Q15388	A0A0S2Z410 Q99714
PDB IDs		4APO	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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