CD44 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CD44	CCND2
Description		CD44 molecule (Indian blood group)	cyclin D2
Image
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity
Drugs		Hyaluronic acid
Diseases		Gastric cancer	Testicular cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)	Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 28869590)
Interacting Genes		61 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	63 interacting genes: ABCB5 ABL1 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		960	894
HPRD ID		00115	00451
Ensembl ID		ENSG00000026508	ENSG00000118971
Uniprot IDs		P16070	P30279
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4	6EI2
Enriched GO Terms of Interacting Partners?
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