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CD44 and CD74
Number of citations of the paper that reports this interaction (PubMedID
8343954
)
50
Data Source:
HPRD
(in vivo)
CD44
CD74
Description
CD44 molecule (Indian blood group)
CD74 molecule
Image
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Focal Adhesion
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Secretory Granule Membrane
Lamellipodium Membrane
Macrophage Migration Inhibitory Factor Receptor Complex
Cell Projection
Extracellular Exosome
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Protein Binding
Collagen Binding
Hyaluronic Acid Binding
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Binding Involved In Protein Folding
Nitric-oxide Synthase Binding
Biological Process
Inflammatory Response
Cell Adhesion
Cell-matrix Adhesion
Cell Migration
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Hyaluronan Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Heterotypic Cell-cell Adhesion
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Wound Healing, Spreading Of Cells
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Cartilage Development
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Cell-cell Adhesion
Positive Regulation Of Monocyte Aggregation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Lamellipodium Morphogenesis
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Defense Response
Cell Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Kinase Activity
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of Chemokine Biosynthetic Process
Positive Regulation Of Interleukin-6 Biosynthetic Process
Positive Regulation Of Interleukin-8 Biosynthetic Process
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation
Interferon gamma signaling
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Drugs
Hyaluronic acid
Diseases
Gastric cancer
GWAS
Bone mineral density (hip) (
30172743
)
Glycemic traits (pleiotropy) (
31021400
)
Intake of sweets (
31005972
)
Response to Vitamin E supplementation (
22437554
)
Systemic lupus erythematosus (
27399966
23273568
26502338
28714469
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Total body bone mineral density (
29304378
)
Uterine fibroids (
31649266
)
Vitiligo (
27723757
22561518
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
61 interacting genes:
ABCB5
AKT1
ANK1
ARHGEF1
ARHGEF12
ARNT
CCND2
CD4
CD74
CDK4
CDK6
CDKN2A
CDKN2B
COL14A1
COL1A1
COL1A2
CSK
DMP1
EGFR
EPB41
EPHA2
ERBB2
ERBB4
EZR
FGF2
FGFR4
FN1
FYN
GARS1
GLIS2
GRM1
HBEGF
HMMR
IGFBP3
KDELR2
LATS2
LCK
MADCAM1
MAP2K3
MAP2K5
MDM4
MET
MMP1
MMP7
MMP9
MSN
NF2
PDGFRA
PKN1
RAF1
SELE
SPP1
SRC
SRGN
STK11
TGFBR1
TGFBR2
TIAM1
VAV2
VCAN
VHL
16 interacting genes:
APP
CD1D
CD44
CTSF
CTSL
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
MAP3K1
MIF
Entrez ID
960
972
HPRD ID
00115
00825
Ensembl ID
ENSG00000026508
ENSG00000019582
Uniprot IDs
P16070
P04233
PDB IDs
1POZ
1UUH
2I83
4PZ3
4PZ4
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
Enriched GO Terms of Interacting Partners
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