CCND2 and MAP2K5

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CCND2	MAP2K5
Description		cyclin D2	mitogen-activated protein kinase kinase 5
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane	Nucleus Cytoplasm Spindle Cytosol
	Molecular Function	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Positive Regulation Of Cell Growth Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of NF-kappaB Transcription Factor Activity Activation Of Protein Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity	Signalling to ERK5
Drugs
Diseases		Testicular cancer
GWAS		Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 28869590)	Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Restless legs syndrome ( 17637780 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Type 2 diabetes ( 30297969) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		63 interacting genes: ABCB5 ABL1 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2	49 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ
Entrez ID		894	5607
HPRD ID		00451	03951
Ensembl ID		ENSG00000118971	ENSG00000137764
Uniprot IDs		P30279	A0A024R5X5 A0A024R5Y2 Q13163
PDB IDs		6EI2	2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?
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