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CD44 and HBEGF
Number of citations of the paper that reports this interaction (PubMedID
7532176
)
76
Data Source:
HPRD
(in vivo)
CD44
HBEGF
Description
CD44 molecule (Indian blood group)
heparin binding EGF like growth factor
Image
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Focal Adhesion
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Secretory Granule Membrane
Lamellipodium Membrane
Macrophage Migration Inhibitory Factor Receptor Complex
Cell Projection
Extracellular Exosome
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Clathrin-coated Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Protein Binding
Collagen Binding
Hyaluronic Acid Binding
Epidermal Growth Factor Receptor Binding
Growth Factor Activity
Heparin Binding
Biological Process
Inflammatory Response
Cell Adhesion
Cell-matrix Adhesion
Cell Migration
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Hyaluronan Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Heterotypic Cell-cell Adhesion
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Wound Healing, Spreading Of Cells
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Cartilage Development
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Cell-cell Adhesion
Positive Regulation Of Monocyte Aggregation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Lamellipodium Morphogenesis
MAPK Cascade
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Muscle Organ Development
Regulation Of Heart Contraction
Positive Regulation Of Cell Proliferation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Wound Healing, Spreading Of Epidermal Cells
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Elastin Biosynthetic Process
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Membrane Organization
Positive Regulation Of Wound Healing
Regulation Of Cell Motility
Pathways
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation
Interferon gamma signaling
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Uptake and function of diphtheria toxin
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Hyaluronic acid
Diseases
Gastric cancer
GWAS
Bone mineral density (hip) (
30172743
)
Glycemic traits (pleiotropy) (
31021400
)
Intake of sweets (
31005972
)
Response to Vitamin E supplementation (
22437554
)
Systemic lupus erythematosus (
27399966
23273568
26502338
28714469
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Total body bone mineral density (
29304378
)
Uterine fibroids (
31649266
)
Vitiligo (
27723757
22561518
)
Alzheimer's disease (
28183528
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Atrial fibrillation (
28416822
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Creatine kinase levels (
29403010
)
General cognitive ability (
29844566
)
Intelligence (MTAG) (
29326435
)
Interacting Genes
61 interacting genes:
ABCB5
AKT1
ANK1
ARHGEF1
ARHGEF12
ARNT
CCND2
CD4
CD74
CDK4
CDK6
CDKN2A
CDKN2B
COL14A1
COL1A1
COL1A2
CSK
DMP1
EGFR
EPB41
EPHA2
ERBB2
ERBB4
EZR
FGF2
FGFR4
FN1
FYN
GARS1
GLIS2
GRM1
HBEGF
HMMR
IGFBP3
KDELR2
LATS2
LCK
MADCAM1
MAP2K3
MAP2K5
MDM4
MET
MMP1
MMP7
MMP9
MSN
NF2
PDGFRA
PKN1
RAF1
SELE
SPP1
SRC
SRGN
STK11
TGFBR1
TGFBR2
TIAM1
VAV2
VCAN
VHL
12 interacting genes:
BAG1
CD44
CD82
CD9
EGFR
ERBB4
FBLN1
LTBP3
MMP7
NRDC
REEP5
ZBTB16
Entrez ID
960
1839
HPRD ID
00115
00526
Ensembl ID
ENSG00000026508
ENSG00000113070
Uniprot IDs
P16070
Q99075
PDB IDs
1POZ
1UUH
2I83
4PZ3
4PZ4
1XDT
2M8S
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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