AKAP12 and PRKAR2A

Number of citations of the paper that reports this interaction (PubMedID 11316952)
10

Data Source:
HPRD (in vitro)

		AKAP12	PRKAR2A
Description		A-kinase anchoring protein 12	protein kinase cAMP-dependent type II regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Neuronal Cell Body Schaffer Collateral - CA1 Synapse	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Protein Kinase A Signaling Response To Lipopolysaccharide Hepatic Stellate Cell Activation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Vascular Permeability Modulation Of Chemical Synaptic Transmission Response To Electrical Stimulus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Regulation Of Protein Kinase C Signaling Positive Regulation Of Oligodendrocyte Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Secretion	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			GEM-231
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Chronic myeloid leukemia ( 21540461) Coronary artery disease ( 29212778) Delirium ( 29631748) Heel bone mineral density ( 30598549) Type 2 diabetes ( 25760438)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: ADRB2 EGFR FHL1 GRK2 PRKAR2A PRKCA PTEN	41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1
Entrez ID		9590	5576
HPRD ID		05263	01484
Ensembl ID		ENSG00000131016	ENSG00000114302
Uniprot IDs		Q02952 Q86TJ9	A0A024R2W3 A0A0S2Z472 A8KAH7 P13861
PDB IDs			2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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