PRKAR2A and P4HA2

		PRKAR2A	P4HA2
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	prolyl 4-hydroxylase subunit alpha 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Electron Transport Chain
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Collagen biosynthesis and modifying enzymes
Drugs		GEM-231	Succinic acid L-Proline
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 29875488) Crohn's disease ( 28067908 22412388) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	7 interacting genes: CLNK CREB3 FHL3 P4HB PRKAR2A PRRC2A TNS4
Entrez ID		5576	8974
HPRD ID		01484	11862
Ensembl ID		ENSG00000114302	ENSG00000072682
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	O15460 Q05DA4
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY	6EVL 6EVM 6EVN 6EVO 6EVP
Enriched GO Terms of Interacting Partners?
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