PRKAR2A and AKAP13

Number of citations of the paper that reports this interaction (PubMedID 1618839)
109

Data Source:
HPRD (in vivo, in vitro)

		PRKAR2A	AKAP13
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 13
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Nucleus Cytosol Actin Filament Cell Cortex Membrane Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	CAMP-dependent Protein Kinase Activity MAP-kinase Scaffold Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Heart Development Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Cell Growth Involved In Cardiac Muscle Cell Development Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		GEM-231
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)	Birth weight ( 31043758) Central corneal thickness ( 31798171 29760442 20719862) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Idiopathic pulmonary fibrosis ( 29066090) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Psoriasis ( 25939698) Pulse pressure ( 30578418) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418)
Interacting Genes		41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	22 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5576	11214
HPRD ID		01484	05253
Ensembl ID		ENSG00000114302	ENSG00000170776
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	A8MYJ1 B0AZU4 Q12802
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY	2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?
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