PRKAR2A and RAB32

Number of citations of the paper that reports this interaction (PubMedID 12186851)
79

Data Source:
HPRD (two hybrid, in vitro)

		PRKAR2A	RAB32
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	RAB32, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Mitochondrion Mitochondrial Outer Membrane Early Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Endomembrane System Membrane Phagocytic Vesicle Membrane Early Endosome Lumen Melanosome Membrane Melanosome Mitochondria-associated ER Membrane Phagocytic Vesicle
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Intracellular Protein Transport Mitochondrion Organization Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Rab Protein Signal Transduction Endosome To Melanosome Transport Protein Localization To Membrane Phagosome Maturation Melanosome Assembly
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		GEM-231
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)	Leprosy ( 27976721 25642632 22019778) Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	2 interacting genes: CHM PRKAR2A
Entrez ID		5576	10981
HPRD ID		01484	06700
Ensembl ID		ENSG00000114302	ENSG00000118508
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	Q13637
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY	4CYM 4CZ2 5OEC 5OED 6FF8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?